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KMID : 0816120110140030258
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Korean Journal of Pediatric Gastroenterolology and Nutrition
2011 Volume.14 No. 3 p.258 ~ p.268
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FOXP3+T Cells and TGF-?1 in Colonic Mucosa of Children with Crohn’s Disease
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Gil Joo-Hyun
Oh Jung-Eun
Seo Jeong-Wan
Cho Min-Sun
Cho Ky-Young
Yoo Eun-Sun
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Abstract
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Purpose: Forkhead box protein 3 (FOXP3)+T cells are the major regulatory T cells controlling all aspects of the immune response. Transforming growth factor-? (TGF-?) is a suppressive cytokine which mediates the suppressive action of FOXP3+T cells. The aim of this study was to investigate the role of FOXP3+T cells, TGF-? in colonic mucosa of children with Crohn’s disease (CD).
Methods: Colonic mucosal biopsies were obtained from 10 children with CD (12∼15 years of age) and 11 control (8∼15 years of age). Frequencies of FOXP3+T, CD4+T cells and TGF-?1 expression were examined in the lamina propria (LP) and lymphoid aggregates or follicles (LA/F) by immunohistochemistry, and later evaluated by association with disease activity.
Results: In the LP of CD group, frequencies of FOXP3+T, CD4+T cells, proportion of FOXP3/CD4+T cells and TGF-?1 expression significantly increased compared to the control. In the LA/F of CD group, frequency of FOXP3+T cells, proportion of FOXP3/CD4+T cells and TGF-?1 expression significantly increased compared to the control (p＜0.05). CD4+T cells also increased compared to the control, but this finding was not significant. In the LP and LA/F of CD group, frequency of FOXP3+T cells exhibited positive correlation with CD4+T cells (p＜0.05). In the LP and LA/F of CD group, TGF-?1 expression had positive correlation with CRP, Pediatric Crohn’s Disease Activity Index, and negative correlation with hematocrit and albumin (p＜0.05).
Conclusion: Increased frequency of FOXP3+T cells and TGF-?1 expression in colonic mucosa of CD can be interpreted as a compensatory increase towards achieving down-regulation of immune responses.
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KEYWORD
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T-lymphocytes, Regulatory, Crohn’s disease, FOXP3, CD4, Transforming growth factor beta, Child, Disease activity
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